Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC6056546 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature communications 20180723 1
The capsaicin receptor TRPV1 has been intensively studied by cryo-electron microscopy and functional tests. However, though the apo and capsaicin-bound structural models are available, the dynamic process of capsaicin activation remains intangible, largely due to the lack of a capsaicin-induced open structural model and the low occupancy of the transition states. Here we report that reducing temperature toward the freezing point substantially increased channel closure events even in the presence ...[more]