Dataset Information

Visual tool for real-time monitoring of membrane fouling via Raman spectroscopy and process model based on principal component analysis.

ABSTRACT: Membrane fouling, i.e. accumulation of unwanted material on the surface of the membrane is a significant problem in filtration processes since it commonly degrades membrane performance and increases operating costs. Therefore, the advantages of early stage monitoring and control of fouling are widely recognized. In this work, the potential of using Raman spectroscopy coupled to chemometrics in order to quantify degree of membrane fouling in real-time was investigated. The Raman data set collected from adsorption experiments with varying pHs and concentrations of model compound vanillin was used to develop a predictive model based on principal component analysis (PCA) for the quantification of the vanillin adsorbed on the membrane. The correspondence between the predicted concentrations based on the PCA model and actual measured concentrations of adsorbed vanillin was moderately good. The model developed was successful in monitoring both adsorption and desorption processes. Furthermore, the model was able to detect abnormally proceeding experiment based on differentiating PCA score and loading values. The results indicated that the presented approach of using Raman spectroscopy combined with a PCA model has potential for use in monitoring and control of fouling and cleaning in membrane processes.

SUBMITTER: Virtanen T

PROVIDER: S-EPMC6056556 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Visual tool for real-time monitoring of membrane fouling via Raman spectroscopy and process model based on principal component analysis.

Virtanen Tiina T Reinikainen Satu-Pia SP Lahti Jussi J Mänttäri Mika M Kallioinen Mari M

Scientific reports 20180723 1

Membrane fouling, i.e. accumulation of unwanted material on the surface of the membrane is a significant problem in filtration processes since it commonly degrades membrane performance and increases operating costs. Therefore, the advantages of early stage monitoring and control of fouling are widely recognized. In this work, the potential of using Raman spectroscopy coupled to chemometrics in order to quantify degree of membrane fouling in real-time was investigated. The Raman data set collecte ...[more]

PMID: 30038320

Similar Datasets

Project description:There is continued focus on the development of new biomaterials and associated biological testing methods needed to reduce the time taken for their entry to clinical use. The application of Raman spectroscopy to the study of individual cells that have been in contact with biomaterials offers enhanced in vitro information in a potentially non-destructive testing regime. The work presented here reports the Raman spectral analysis of discreet U-2 OS bone cells after exposure to hydroxyapatite (HA) coated titanium (Ti) substrates in both the as-deposited and thermally annealed states. These data show that cells that were in contact with the bioactive HA surface for 7 days had spectral markers similar to those cultured on the Ti substrate control for the same period. However, the spectral features for those cells that were in contact with the annealed HA surface had indicators of significant differentiation at day 21 while cells on the as-deposited surface did not show these Raman changes until day 28. The cells adhered to pristine Ti control surface showed no spectral changes at any of the timepoints studied. The validity of these spectroscopic results has been confirmed using data from standard in vitro cell viability, adhesion, and proliferation assays over the same 28-day culture period. In this case, cell maturation was evidenced by the formation of natural bone apatite, which precipitated intracellularly for cells exposed to both types of HA-coated Ti at 21 and 28 days, respectively. The properties of the intracellular apatite were markedly different from that of the synthetic HA used to coat the Ti substrate with an average particle size of 230 nm, a crystalline-like shape and Ca/P ratio of 1.63 ± 0.5 as determined by SEM-EDX analysis. By comparison, the synthetic HA particles used as a control had an average size of 372 nm and were more-rounded in shape with a Ca/P ratio of 0.8 by XPS analysis and 1.28 by SEM-EDX analysis. This study shows that Raman spectroscopy can be employed to monitor single U-2 OS cell response to biomaterials that promote cell maturation towards de novo bone thereby offering a label-free in vitro testing method that allows for non-destructive analyses.

Dataset Information

Visual tool for real-time monitoring of membrane fouling via Raman spectroscopy and process model based on principal component analysis.

Publications

Visual tool for real-time monitoring of membrane fouling via Raman spectroscopy and process model based on principal component analysis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets