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Phylogenetic analysis and genotype distribution of Hepatitis B Virus (HBV) in Roraima, Brazil.


ABSTRACT: Hepatitis B virus (HBV) infection is a serious global health problem. HBV has a high viral genetic diversity, with 10 genotypes recognized. In Brazil, the Roraima State is the third in the Northern region regarding the number of hepatitis B cases. On the other hand, few data on HBV genotyping and phylogenetic analysis are available. The purpose of this study is to characterize the HBV genotypes circulating in Roraima State. Of the 113 chronic hepatitis B patients enrolled in this study, 40 were HBV-DNA positive. A fragment of 280 bp (S gene) was amplified by PCR and submitted to nucleotide sequencing. A dataset containing the viral sequences obtained in this study, plus 130 obtained from GenBank was used for genotyping by phylogenetic analysis. The HBV subgenotype distribution found was A1 (62.5%), A2 (7.5%), D2, D3, D4 (2.5%), F2a (12.5%), and F3 (10%). We characterized the genotypes and subgenotypes of HBV circulating among patients in the State of Roraima. In addition, our study shows for the first time the HBV/F3 genotype circulating in Brazil. In conclusion, our findings showed a high diversity of HBV genotypes in Roraima, which is also found in other Brazilian geographical regions.

SUBMITTER: Sousa DD 

PROVIDER: S-EPMC6056886 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Phylogenetic analysis and genotype distribution of Hepatitis B Virus (HBV) in Roraima, Brazil.

Sousa Débora Dinelly de DD   Silva Claudiane Raquel de Sousa CRS   Lima Junior Wilson Pereira WP   Barros Jacqueline de Aguiar JA   Nascimento Ismael Alexandre da Silva IADS   Souza Victor Costa de VC   Naveca Felipe Gomes FG   Granja Fabiana F  

Revista do Instituto de Medicina Tropical de Sao Paulo 20180719


Hepatitis B virus (HBV) infection is a serious global health problem. HBV has a high viral genetic diversity, with 10 genotypes recognized. In Brazil, the Roraima State is the third in the Northern region regarding the number of hepatitis B cases. On the other hand, few data on HBV genotyping and phylogenetic analysis are available. The purpose of this study is to characterize the HBV genotypes circulating in Roraima State. Of the 113 chronic hepatitis B patients enrolled in this study, 40 were  ...[more]

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