Ontology highlight
ABSTRACT:
SUBMITTER: Berry S
PROVIDER: S-EPMC6057643 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Berry Stewart S Weinmann Oliver O Fritz Ann-Kristina AK Rust Ruslan R Wolfer David D Schwab Martin E ME Gerber Urs U Ster Jeanne J
PloS one 20180724 7
Recent investigations of Nogo-A, a well characterized protein inhibitor of neurite outgrowth in the brain, have revealed additional functions including a role in neuropsychiatric disorders such as schizophrenia. Here we examined Nogo-A functions in mouse CA3 hippocampal circuitry. Patch clamp recordings showed that the absence of Nogo-A results in a hyperactive network. In addition, mGlu3 metabotropic glutamate receptors, which exhibit mutations in certain forms of schizophrenia, were downregula ...[more]