Germline and somatic mtDNA mutations in mouse aging.
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ABSTRACT:
SUBMITTER: Ma H
PROVIDER: S-EPMC6057648 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Germline and somatic mtDNA mutations in mouse aging.
Ma Hong H Lee Yeonmi Y Hayama Tomonari T Van Dyken Crystal C Marti-Gutierrez Nuria N Li Ying Y Ahmed Riffat R Koski Amy A Kang Eunju E Darby Hayley H Gonmanee Thanasup T Park Younjung Y Wolf Don P DP Jai Kim Chong C Mitalipov Shoukhrat S
PloS one 20180724 7
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2-34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve ...[more]
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