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Study of the Room-Temperature Synthesis of Oxime Ethers by using a Super Base.

ABSTRACT: In this study, we present a convenient method for the synthesis of oxime ethers by reacting oximes with various chlorides (alkyl, functionalized alkyl, and benzyl) and with the subsequent use of a super base-pulverized potassium hydroxide in DMSO. The reactions take place at room temperature and the products are obtained in high yields. The final products were received within 2?min to 3?h. In addition, the compounds do not require chromatographic separation. The structure elucidation of the titled compounds was performed by using ¹H?NMR and ¹³C?NMR spectroscopy as well as mass spectrometry. The presented method of synthesis for oxime ethers is environmentally friendly, because neither water cooling or heating of the reaction mixture/solvents (necessary for chromatographic purification) is required. The synthesis can be carried out very easily on a large scale.

SUBMITTER: Kosmalski T

PROVIDER: S-EPMC6058178 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Study of the Room-Temperature Synthesis of Oxime Ethers by using a Super Base.

Kosmalski Tomasz T Studzińska Renata R Daniszewska Natalia N Ullrich Małgorzata M Sikora Adam A Marszałł Michał M Modzelewska-Banachiewicz Bożena B

ChemistryOpen 20180725 7

In this study, we present a convenient method for the synthesis of oxime ethers by reacting oximes with various chlorides (alkyl, functionalized alkyl, and benzyl) and with the subsequent use of a super base-pulverized potassium hydroxide in DMSO. The reactions take place at room temperature and the products are obtained in high yields. The final products were received within 2 min to 3 h. In addition, the compounds do not require chromatographic separation. The structure elucidation of the titl ...[more]

PMID: 30065906

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