[Clinical Evaluation of A New Pathological Classification for ?Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree].
Ontology highlight
ABSTRACT: BACKGROUND:Due in part to remarkable advances over the past decade in our understanding of lung cancer, there is a pressing need for a revised classification. The aim of this study was to explore and verify the clinical significance of a new molecular classification of non-small cell lung cancer (NSCLC) on the basis of anatomic site of bronchial tree. METHODS:Double-immunohistochemistry were performed in 105 tumor samples paring with normal lung tissue from non-small cell lung cancer patients by using monoclonal antibody of P63/NapsinA and TTF-1/CK7. By comprehensively analyzing the express profiles of tumors and normal lung tissues, histological characteristics we proposed a brand new pathological classification based on histogenesis for NSCLC and divided them as: bronchiole epithelial cell carcinoma, bronchiole-alveolar cell carcinoma, alveolar cell carcinoma and secretory adenocarcinoma. And to analyze the relationship between this classification and epidermal growth factor receptor (EGFR) mutation and ognosis. RESULTS:Further investigation revealed that our new classification showed strong relevancy with EGFR mutations and effective indicators for prognosis. CONCLUSIONS:The classification system for NSCLC proposed by our research group is convenient for pathological diagnosis and valuable in clinical application.
SUBMITTER: Wang N
PROVIDER: S-EPMC6058656 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
ACCESS DATA