Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma.
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ABSTRACT:
SUBMITTER: Roelants C
PROVIDER: S-EPMC6059021 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma.
Roelants Caroline C Giacosa Sofia S Pillet Catherine C Bussat Rémi R Champelovier Pierre P Bastien Olivier O Guyon Laurent L Arnoux Valentin V Cochet Claude C Filhol Odile O
Oncotarget 20180710 53
Potent inhibitors of PI3K (GDC-0941) and Src (Saracatinib) exhibit as individual agents, excellent oral anticancer activity in preclinical models and have entered phase II clinical trials in various cancers. We found that PI3K and Src kinases are dysregulated in clear cell renal carcinomas (ccRCCs), an aggressive disease without effective targeted therapies. In this study we addressed this challenge by testing GDC-0941 and Saracatinib as either single agents or in combination in ccRCC cell lines ...[more]
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