Ontology highlight
ABSTRACT:
SUBMITTER: Zwang Y
PROVIDER: S-EPMC5479695 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Zwang Yaara Y Jonas Oliver O Chen Casandra C Rinne Mikael L ML Doench John G JG Piccioni Federica F Tan Li L Huang Hai-Tsang HT Wang Jinhua J Ham Young Jin YJ O'Connell Joyce J Bhola Patrick P Doshi Mihir M Whitman Matthew M Cima Michael M Letai Anthony A Root David E DE Langer Robert S RS Gray Nathanael N Hahn William C WC
eLife 20170531
Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for genes that are required for the survival of PI3K mutant cancer cells in the presence of PI3K inhibition by conducting a genome scale shRNA-based apoptosis screen in a <i>PIK3CA</i> mutant human breast cancer cell. We identified 5 genes (<i>PIM2, ZAK, TA ...[more]