Ontology highlight
ABSTRACT:
SUBMITTER: Hoye AM
PROVIDER: S-EPMC6059023 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Høye Anette M AM Tolstrup Sofie D SD Horton Edward R ER Nicolau Monica M Frost Helen H Woo Jung H JH Mauldin Jeremy P JP Frankel Arthur E AE Cox Thomas R TR Erler Janine T JT
Oncotarget 20180710 53
Every year more than 8 million people suffer from cancer-related deaths worldwide [1]. Metastasis, the spread of cancer to distant sites, accounts for 90% of these deaths. A promising target for blocking tumor progression, without causing severe side effects [2], is Tumor Endothelial Marker 8 (TEM8), an integrin-like cell surface protein expressed predominantly in the tumor endothelium and in cancer cells [3, 4]. Here, we have investigated the role of TEM8 in cancer progression, angiogenesis and ...[more]