Host-derived tumor endothelial marker 8 promotes the growth of melanoma.
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ABSTRACT:
SUBMITTER: Cullen M
PROVIDER: S-EPMC2721800 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Host-derived tumor endothelial marker 8 promotes the growth of melanoma.
Cullen Mike M Seaman Steven S Chaudhary Amit A Yang Mi Young MY Hilton Mary Beth MB Logsdon Daniel D Haines Diana C DC Tessarollo Lino L St Croix Brad B
Cancer research 20090721 15
Tumor endothelial marker 8 (TEM8) was initially identified as a gene overexpressed in the vasculature of human tumors and was subsequently identified as an anthrax toxin receptor. To assess the functional role of TEM8, we disrupted the TEM8 gene in mice by targeted homologous recombination. TEM8(-/-) mice were viable and reached adulthood without defects in physiologic angiogenesis. However, histopathologic analysis revealed an excess of extracellular matrix in several tissues, including the ova ...[more]
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