Ontology highlight
ABSTRACT:
SUBMITTER: Headen DM
PROVIDER: S-EPMC6060019 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Headen Devon M DM Woodward Kyle B KB Coronel María M MM Shrestha Pradeep P Weaver Jessica D JD Zhao Hong H Tan Min M Hunckler Michael D MD Bowen William S WS Johnson Christopher T CT Shea Lonnie L Yolcu Esma S ES García Andrés J AJ Shirwan Haval H
Nature materials 20180604 8
Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces morbidities and impairs islet function. T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensitive to Fas-mediated apoptosis. Here, we report that localized immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin (SA-FasL) results ...[more]