Ontology highlight
ABSTRACT:
SUBMITTER: Coronel MM
PROVIDER: S-EPMC7455180 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Coronel María M MM Martin Karen E KE Hunckler Michael D MD Barber Graham G O'Neill Eric B EB Medina Juan D JD Opri Enrico E McClain Claire A CA Batra Lalit L Weaver Jessica D JD Lim Hong S HS Qiu Peng P Botchwey Edward A EA Yolcu Esma S ES Shirwan Haval H García Andrés J AJ
Science advances 20200828 35
Antibody-mediated immune checkpoint blockade is a transformative immunotherapy for cancer. These same mechanisms can be repurposed for the control of destructive alloreactive immune responses in the transplantation setting. Here, we implement a synthetic biomaterial platform for the local delivery of a chimeric streptavidin/programmed cell death-1 (SA-PD-L1) protein to direct "reprogramming" of local immune responses to transplanted pancreatic islets. Controlled presentation of SA-PD-L1 on the s ...[more]