Ontology highlight
ABSTRACT:
SUBMITTER: Hynes AP
PROVIDER: S-EPMC6060171 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature communications 20180725 1
CRISPR-Cas systems are bacterial anti-viral systems, and bacterial viruses (bacteriophages, phages) can carry anti-CRISPR (Acr) proteins to evade that immunity. Acrs can also fine-tune the activity of CRISPR-based genome-editing tools. While Acrs are prevalent in phages capable of lying dormant in a CRISPR-carrying host, their orthologs have been observed only infrequently in virulent phages. Here we identify AcrIIA6, an Acr encoded in 33% of virulent Streptococcus thermophilus phage genomes. Th ...[more]