Ontology highlight
ABSTRACT:
SUBMITTER: He F
PROVIDER: S-EPMC11249088 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
He Fei F Bhoobalan-Chitty Yuvaraj Y Van Lan B LB Kjeldsen Anders L AL Dedola Matteo M Makarova Kira S KS Koonin Eugene V EV Brodersen Ditlev E DE Peng Xu X
Nature microbiology 20180305 4
Viruses employ a range of strategies to counteract the prokaryotic adaptive immune system, clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas), including mutational escape and physical blocking of enzymatic function using anti-CRISPR proteins (Acrs). Acrs have been found in many bacteriophages but so far not in archaeal viruses, despite the near ubiquity of CRISPR-Cas systems in archaea. Here, we report the functional and structural characterizat ...[more]