Ontology highlight
ABSTRACT:
SUBMITTER: de Carvalho LP
PROVIDER: S-EPMC6060200 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
de Carvalho Leonardo P LP Tan Sock Hwee SH Ow Ghim-Siong GS Tang Zhiqun Z Ching Jianhong J Kovalik Jean-Paul JP Poh Sock Cheng SC Chin Chee-Tang CT Richards A Mark AM Martinez Eliana C EC Troughton Richard W RW Fong Alan Yean-Yip AY Yan Bryan P BP Seneviratna Aruni A Sorokin Vitaly V Summers Scott A SA Kuznetsov Vladimir A VA Chan Mark Y MY
JACC. Basic to translational science 20180401 2
We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a ...[more]