Ontology highlight
ABSTRACT:
SUBMITTER: Skalski M
PROVIDER: S-EPMC6060993 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Skalski Marcin M Ustaszewski Adam A Jaskiewicz Katarzyna K Kiwerska Katarzyna K Wierzbicka Malgorzata M Klimza Hanna H Grenman Reidar R Giefing Maciej M
Journal of applied genetics 20180429 3
The miRNA-196a2 has shown significance in the development of various neoplasms, including head and neck squamous cell carcinoma (HNSCC). The oncogenic functionality of this miRNA is mediated via its potential to target annexin A1 mRNA, a tumor suppressor gene involved in inhibition of the NF-κB pathway. Interestingly, recent data indicate a susceptibility for aforementioned neoplasms in patients with the CC genotype vs the CT and TT genotypes of the rs11614913 SNP located within the DNA sequence ...[more]