Ontology highlight
ABSTRACT:
SUBMITTER: Leeman M
PROVIDER: S-EPMC6061777 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Leeman Mats M Choi Jaeyeong J Hansson Sebastian S Storm Matilda Ulmius MU Nilsson Lars L
Analytical and bioanalytical chemistry 20180529 20
The analysis of aggregates of therapeutic proteins is crucial in order to ensure efficacy and patient safety. Typically, the analysis is performed in the finished formulation to ensure that aggregates are not present. An important question is, however, what happens to therapeutic proteins, with regard to oligomerization and aggregation, after they have been administrated (i.e., in the blood). In this paper, the separation of whole blood, plasma, and serum is shown using asymmetric flow field-flo ...[more]