Ontology highlight
ABSTRACT:
SUBMITTER: Gao A
PROVIDER: S-EPMC6061855 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Gao Ang A Vasilyev Nikita N Luciano Daniel J DJ Levenson-Palmer Rose R Richards Jamie J Marsiglia William M WM Traaseth Nathaniel J NJ Belasco Joel G JG Serganov Alexander A
Nucleic acids research 20180701 13
Vitally important for controlling gene expression in eukaryotes and prokaryotes, the deprotection of mRNA 5' termini is governed by enzymes whose activity is modulated by interactions with ancillary factors. In Escherichia coli, 5'-end-dependent mRNA degradation begins with the generation of monophosphorylated 5' termini by the RNA pyrophosphohydrolase RppH, which can be stimulated by DapF, a diaminopimelate epimerase involved in amino acid and cell wall biosynthesis. We have determined crystal ...[more]