Ontology highlight
ABSTRACT:
SUBMITTER: Araiso Y
PROVIDER: S-EPMC2275076 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Araiso Yuhei Y Palioura Sotiria S Ishitani Ryuichiro R Sherrer R Lynn RL O'Donoghue Patrick P Yuan Jing J Oshikane Hiroyuki H Domae Naoshi N Defranco Julian J Söll Dieter D Nureki Osamu O
Nucleic acids research 20071223 4
The micronutrient selenium is present in proteins as selenocysteine (Sec). In eukaryotes and archaea, Sec is formed in a tRNA-dependent conversion of O-phosphoserine (Sep) by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS). Here, we present the crystal structure of Methanococcus maripaludis SepSecS complexed with PLP at 2.5 A resolution. SepSecS, a member of the Fold Type I PLP enzyme family, forms an (alpha2)2 homotetramer through its N-terminal extension. The active site lies on th ...[more]