Ontology highlight
ABSTRACT:
SUBMITTER: Tropini C
PROVIDER: S-EPMC6061967 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Cell 20180601 7
Osmotic diarrhea is a prevalent condition in humans caused by food intolerance, malabsorption, and widespread laxative use. Here, we assess the resilience of the gut ecosystem to osmotic perturbation at multiple length and timescales using mice as model hosts. Osmotic stress caused reproducible extinction of highly abundant taxa and expansion of less prevalent members in human and mouse microbiotas. Quantitative imaging revealed decimation of the mucus barrier during osmotic perturbation, follow ...[more]