Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota.
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ABSTRACT:
SUBMITTER: Tropini C
PROVIDER: S-EPMC6061967 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota.
Tropini Carolina C Moss Eli Lin EL Merrill Bryan Douglas BD Ng Katharine Michelle KM Higginbottom Steven Kyle SK Casavant Ellen Pun EP Gonzalez Carlos Gutierrez CG Fremin Brayon B Bouley Donna Michelle DM Elias Joshua Eric JE Bhatt Ami Siddharth AS Huang Kerwyn Casey KC Sonnenburg Justin Laine JL
Cell 20180601 7
Osmotic diarrhea is a prevalent condition in humans caused by food intolerance, malabsorption, and widespread laxative use. Here, we assess the resilience of the gut ecosystem to osmotic perturbation at multiple length and timescales using mice as model hosts. Osmotic stress caused reproducible extinction of highly abundant taxa and expansion of less prevalent members in human and mouse microbiotas. Quantitative imaging revealed decimation of the mucus barrier during osmotic perturbation, follow ...[more]
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