Effects of sub-chronic exposure to atmospheric PM2.5 on fibrosis, inflammation, endoplasmic reticulum stress and apoptosis in the livers of rats.
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ABSTRACT:
SUBMITTER: Li R
PROVIDER: S-EPMC6062260 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
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Effects of sub-chronic exposure to atmospheric PM<sub>2.5</sub> on fibrosis, inflammation, endoplasmic reticulum stress and apoptosis in the livers of rats.
Li Ruijin R Zhang Mei M Wang Ying Y Yung Ken Kin Lam KKL Su Ruijun R Li Zhuoyu Z Zhao Liping L Dong Chuan C Cai Zongwei Z
Toxicology research 20180110 2
Epidemiological studies have revealed that exposure to PM<sub>2.5</sub> is linked to liver cancer. However, the hepatic toxicity and relevant molecular mechanisms of PM<sub>2.5</sub> have not yet been fully described. Herein, we report on our investigation of the fibrosis, inflammation, endoplasmic reticulum (ER) stress and apoptosis in the livers of rats, caused by exposure to PM<sub>2.5</sub> during summer and winter in Taiyuan, China. Male SD rats were sub-chronically exposed to PM<sub>2.5</s ...[more]
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