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Individual heavy metal exposure and birth outcomes in Shenqiu county along the Huai River Basin in China.

ABSTRACT: Background: Exposure to heavy metals during pregnancy is an important risk factor for adverse birth outcomes. We aimed to investigate the current heavy metal exposure levels in cord blood from healthy pregnant women residing in the Huaihe River Basin, China, and examined the association between heavy metal levels and dietary habits and lifestyle factors. In this study, we measured the exposure levels of five heavy metals in the umbilical cord blood from 350 healthy pregnant women and administered 350 self-reported questionnaires regarding the general characteristics and dietary habits of those women. Methods: This study was undertaken in Shenqiu county, Henan province, which is in the area of the Huai River Basin, in a cohort of pregnant women and newborn babies in 2013-2014. We recruited a sample of 1000 pregnant women among those receiving prenatal examination, measured the real individual newborn exposure to heavy metals in serum by ICP-MS, collected information regarding the pregnant women with a questionnaire survey and obtained data on environmental quality from environmental protection agencies and the available literature. We estimated the daily individual exposure to heavy metals of all the 1000 participants throughout the pregnancy and recorded their birth outcomes after delivery. Then we analyzed the association between birth outcome and individual exposure to heavy metals. Results: 54 newborn children had birth defects. The geometric means of cord blood levels of As, Cd, Cr, Pb and Hg were measured at 0.92 ± 1.01 ng mL-1, 0.11 ± 0.17 ng mL-1, 4.57 ± 5.02 ng mL-1, 3.37 ± 3.81 ng mL-1 and 0.89 ± 1.69 ng mL-1 for subjects (n = 54) who gave birth to infants with birth defects and 0.43 ± 0.88 ng mL-1, 0.52 ± 3.86 ng mL-1, 1.94 ± 2.92 ng mL-1, 4.38 ± 4.96 ng mL-1 and 0.43 ± 0.91 ng mL-1 for subjects (n = 296) with healthy infants, respectively. The contents of all five heavy metals in the whole blood of both of these two groups were higher than the reference values of the Chinese general population (P < 0.001). Conclusions: The occurrence of birth defects was 15.4% in this cohort, and was correlated to exposure of parents to environments containing heavy metal contaminants in Shenqiu county in the Huai River Basin. The heavy metal exposure situation of the investigated population had serious effects in terms of reproductive defects in children. The specific link between newborn defects and environmental heavy metal contaminants suggested that contamination in pregnant women persisted over time, and that the exposure may have a long term effect.

SUBMITTER: Lin Z

PROVIDER: S-EPMC6062375 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Individual heavy metal exposure and birth outcomes in Shenqiu county along the Huai River Basin in China.

Lin Zhiqing Z Chen Xi X Xi Zhuge Z Lin Shaobin S Sun Xin X Jiang Xiao X Tian Haoyuan H

Toxicology research 20180307 3

<i>Background</i>: Exposure to heavy metals during pregnancy is an important risk factor for adverse birth outcomes. We aimed to investigate the current heavy metal exposure levels in cord blood from healthy pregnant women residing in the Huaihe River Basin, China, and examined the association between heavy metal levels and dietary habits and lifestyle factors. In this study, we measured the exposure levels of five heavy metals in the umbilical cord blood from 350 healthy pregnant women and admi ...[more]

PMID: 30090594

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Project description:BackgroundIn 2004, the media repeatedly reported water pollution and "cancer villages" along the Huai River in China. Due to the lack of death records for more than 30 years, a retrospective survey of causes of death using verbal autopsy was carried out to investigate cancer rates in this area.MethodsAn epidemiologic study was designed to compare numbers of deaths and causes of death between the study areas with water pollution and the control areas without water pollution in S County and Y District in 2005. The study areas were selected based on the distribution of the Huai River and its tributaries. Verbal autopsy was used to assist cause of death (COD) diagnoses and to verify mortality rates. The standard mortality rates (SMRs) of cancer in the study area were compared with those in the control areas. In order to verify the difference between mortality rates due to cancers in the study and the control areas, patients who reported having cancer in the survey received a second diagnosis by national and provincial oncologists with pathological and laboratory examinations. Comparisons were made to determine if differential cancer prevalence rates in the study and control areas were similar to the difference in mortality due to cancer in these study and control areas. Mortality rates of cancers in study and control areas were also compared with national statistics for the rural population of China.ResultsOver five years, 3,301 deaths were identified, including 1,158 cancer deaths. The annual average SMRs of cancer in the study areas of S County and Y District were 277.8/100,000 and 223.6/100,000, respectively, which is three to four times higher than those in the control areas. In addition, a total of 626 cases of cancer in the study and control areas were confirmed. The prevalence rates of cancer were 545/100,000 and 128.1/100,000 per year in the study and control areas in S County, respectively, and 440.9/100,000 and 200/100,000 per year in the study and control areas in Y District, respectively. The mortality and prevalence rates of digestive cancers were higher in the study areas than the control areas. In 2000, the SMR for cancer in rural areas nationwide was 120.9/100,000, and in study areas in S County and Y District, the excess rates of deaths were 184/100,000 and 138.8/100,000, respectively.ConclusionsThe death rates of digestive cancers were much higher in the study areas of S County and Y District. The patterns for between-area differences in prevalence and mortality rates of cancer were similar. Verbal autopsy is shown to be a useful tool in retrospective mortality surveys in low-resource areas with limited access to health care.

Project description:In the Syr Darya River watershed, 225 samples from three different layers in 75 soil profiles were collected from irrigated areas in three different spatial regions (I: n = 29; II: n = 17; III: n = 29), and the spatial and vertical variation characteristics of potentially toxic elements (Cd, Co, Cu, Ni, and Zn) and a metallic element (Mn) were studied. The human health risks and enrichment factors were also evaluated in the Syr Darya River watershed of the Aral Sea Basin in Kazakhstan. There were significant differences in the contents of heavy metals in the different soil layers in the different sampling regions. Based on element variation similarity revealed by hierarchical cluster analysis, the elemental groupings were consistent in the different layers only in region I. For regions II and III, the clustered elemental groups were the same between surface layer A and B, but differed from those in the deep layer C. In sampling region I, the heavy metals in surface soils were significantly correlated with the ones in deep layers, reflecting that they were mainly affected by the elemental composition of parent materials. In region II, the significant correlations only existed for Cu, Mn, and Zn between the surface and deep layers. The similar phenomenon with significant correlation was also observed for heavy metals in sampling region III, except for Cd. Finally, enrichment factor was used to study the mobilization and enrichment of potentially toxic elements. The enrichment factors of Zn, Cu, and Cd in surface layer A that were greater than 1.5 accounted for 1.16%, 6.79%, and 24.36% of sampling region I, respectively. In sampling region II, the enrichment factors of Zn, Cu, Cd, and Co that were greater than 1.5 accounted for 0.03%, 4.76%, 0.54%, and 9.03% of the total area, respectively. In sampling region III, only the enrichment factors of Zn, Cu, and Cd that exceeded 1.5 accounted for 0.24%, 4.90%, and 6.89% of the total area, respectively. Although the contents of the heavy metals were not harmful to human health, the effects of human activities on the heavy metals in the irrigated soils revealed by enrichment factors have been shown in this study area.

Project description:The COVID-19 era has profoundly affected everyday human life, the environment, and freshwater ecosystems worldwide. Despite the numerous influences, a strict COVID-19 lockdown might improve the surface water quality and thus provide an unprecedented opportunity to restore the degraded freshwater resource. Therefore, we intend to investigate the spatiotemporal water quality, sources, and preliminary health risks of heavy metal(loid)s in the Karatoya River basin (KRB), a tropical urban river in Bangladesh. Seventy water samples were collected from 35 stations in KRB in 2019 and 2022 during the dry season. The results showed that the concentrations of Ni, Cu, Zn, Pb, Cd, and Cr were significantly reduced by 89.3-99.7 % during the post-lockdown period (p < 0.05). However, pH, Fe, Mn, and As concentrations increased due to the rise of urban waste and the usage of disinfectants during the post-lockdown phase. In the post-lockdown phase, the heavy metal pollution index, heavy metal evaluation index, and Nemerow's pollution index values lessened by 8.58 %, 42.86 %, and 22.86 %, respectively. Besides, the irrigation water quality indices also improved by 59 %-62 %. The total hazard index values increased by 24 % (children) and 22 % (adults) due to the rise in Mn and As concentrations during the lockdown. In comparison, total carcinogenic risk values were reduced by 54 % (children) and 53 % (adults) in the post-lockdown. We found no significant changes in river flow, rainfall, or land cover near the river from the pre to post-lockdown phase. The results of semivariogram models have demonstrated that most attributes have weak spatial dependence, indicating restricted industrial and agricultural effluents during the lockdown, significantly improving river water quality. Our study confirms that the lockdown provides a unique opportunity for the remarkable improvement of degraded freshwater resources. Long-term management policies and regular monitoring should reduce river pollution and clean surface water.

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Individual heavy metal exposure and birth outcomes in Shenqiu county along the Huai River Basin in China.

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Individual heavy metal exposure and birth outcomes in Shenqiu county along the Huai River Basin in China.

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