Ontology highlight
ABSTRACT:
SUBMITTER: Belter A
PROVIDER: S-EPMC4832220 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20160415
Despite tremendous efforts worldwide, glioblastoma multiforme (GBM) remains a deadly disease for which no cure is available and prognosis is very bad. Recently, miR-21 has emerged as a key omnipotent player in carcinogenesis, including brain tumors. It is recognized as an indicator of glioma prognosis and a prosperous target for anti-tumor therapy. Here we show that rationally designed hammerhead ribozymes and DNAzymes can target miR-21 and/or its precursors. They decrease miR-21 level, and thus ...[more]