Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC6062835 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
ACS central science 20180702 7
In designing bioassay systems for low-abundance biomolecule detection, most research focuses on improving transduction mechanisms while ignoring the intrinsically fundamental limitations in solution: mass transfer and binding affinity. We demonstrate enhanced biomolecular surface binding using an acoustic nano-electromechanical system (NEMS) resonator, as an on-chip biomolecular concentrator which breaks both mass transfer and binding affinity limitations. As a result, a concentration factor of ...[more]