Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC6063469 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Wu Chong C Ning Huiheng H Liu Mingyu M Lin Jie J Luo Shufeng S Zhu Wenjie W Xu Jing J Wu Wen-Chao WC Liang Jing J Shao Chun-Kui CK Ren Jiaqi J Wei Bin B Cui Jun J Chen Min-Shan MS Zheng Limin L
The Journal of clinical investigation 20180709 8
Cancer progression is associated with alterations of intra- and extramedullary hematopoiesis to support a systemic tumor-promoting myeloid response. However, the functional specialty, mechanism, and clinical relevance of extramedullary hematopoiesis (EMH) remain unclear. Here, we showed that the heightened splenic myelopoiesis in tumor-bearing hosts was not only characterized by the accumulation of myeloid precursors, but also associated with profound functional alterations of splenic early hema ...[more]