Ontology highlight
ABSTRACT:
SUBMITTER: Lim HK
PROVIDER: S-EPMC6354566 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lim Hong Kiat HK O'Neill Helen C HC
Frontiers in cell and developmental biology 20190124
Stromal cells in spleen organize tissue into red pulp, white pulp and marginal zone, and also interact with hematopoietic cells to regulate immune responses. This study has used phenotypic information of a previously described spleen stromal cell line called 5G3, which supports restricted hematopoiesis <i>in vitro</i>, to identify an equivalent stromal cell subset <i>in vivo</i> and to test its capacity to support hematopoiesis. Using stromal cell fractionation, phenotypic analysis, as well as c ...[more]