Ontology highlight
ABSTRACT:
SUBMITTER: Ballegeer M
PROVIDER: S-EPMC6063488 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ballegeer Marlies M Van Looveren Kelly K Timmermans Steven S Eggermont Melanie M Vandevyver Sofie S Thery Fabien F Dendoncker Karen K Souffriau Jolien J Vandewalle Jolien J Van Wyngene Lise L De Rycke Riet R Takahashi Nozomi N Vandenabeele Peter P Tuckermann Jan J Reichardt Holger M HM Impens Francis F Beyaert Rudi R De Bosscher Karolien K Vandenbroucke Roosmarijn E RE Libert Claude C
The Journal of clinical investigation 20180625 8
TNF is an important mediator in numerous inflammatory diseases, e.g., in inflammatory bowel diseases (IBDs). In IBD, acute increases in TNF production can lead to disease flares. Glucocorticoids (GCs), which are steroids that bind and activate the glucocorticoid receptor (GR), are able to protect animals and humans against acute TNF-induced inflammatory symptoms. Mice with a poor transcriptional response of GR dimer-dependent target genes were studied in a model of TNF-induced lethal inflammatio ...[more]