Ontology highlight
ABSTRACT:
SUBMITTER: Nath SR
PROVIDER: S-EPMC6063498 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nath Samir R SR Yu Zhigang Z Gipson Theresa A TA Marsh Gregory B GB Yoshidome Eriko E Robins Diane M DM Todi Sokol V SV Housman David E DE Lieberman Andrew P AP
The Journal of clinical investigation 20180723 8
Skeletal muscle has emerged as a critical, disease-relevant target tissue in spinal and bulbar muscular atrophy, a degenerative disorder of the neuromuscular system caused by a CAG/polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. Here, we used RNA-sequencing (RNA-Seq) to identify pathways that are disrupted in diseased muscle using AR113Q knockin mice. This analysis unexpectedly identified substantially diminished expression of numerous ubiquitin/proteasome pathway genes in AR ...[more]