Ontology highlight
ABSTRACT:
SUBMITTER: Emoto C
PROVIDER: S-EPMC6063742 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Emoto Chie C Johnson Trevor N TN Neuhoff Sibylle S Hahn David D Vinks Alexander A AA Fukuda Tsuyoshi T
CPT: pharmacometrics & systems pharmacology 20180619 7
Morphine has large pharmacokinetic variability, which is further complicated by developmental changes in neonates and small infants. The impacts of organic cation transporter 1 (OCT1) genotype and changes in blood-flow on morphine clearance (CL) were previously demonstrated in children, whereas changes in UDP-glucuronosyltransferase 2B7 (UGT2B7) activity showed a small effect. This study, targeting neonates and small infants, was designed to assess the influence of developmental changes in OCT1 ...[more]