Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations.
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ABSTRACT:
SUBMITTER: Chen B
PROVIDER: S-EPMC6063786 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations.
Chen Bo B Li Yi Y Yu Bin B Zhang Zicong Z Brommer Benedikt B Williams Philip Raymond PR Liu Yuanyuan Y Hegarty Shane Vincent SV Zhou Songlin S Zhu Junjie J Guo Hong H Lu Yi Y Zhang Yiming Y Gu Xiaosong X He Zhigang Z
Cell 20180719 3
Many human spinal cord injuries are anatomically incomplete but exhibit complete paralysis. It is unknown why spared axons fail to mediate functional recovery in these cases. To investigate this, we undertook a small-molecule screen in mice with staggered bilateral hemisections in which the lumbar spinal cord is deprived of all direct brain-derived innervation, but dormant relay circuits remain. We discovered that a KCC2 agonist restored stepping ability, which could be mimicked by selective exp ...[more]
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