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Scutoids are a geometrical solution to three-dimensional packing of epithelia.

ABSTRACT: As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term "scutoid". The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.

SUBMITTER: Gomez-Galvez P

PROVIDER: S-EPMC6063940 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Scutoids are a geometrical solution to three-dimensional packing of epithelia.

Gómez-Gálvez Pedro P Vicente-Munuera Pablo P Tagua Antonio A Forja Cristina C Castro Ana M AM Letrán Marta M Valencia-Expósito Andrea A Grima Clara C Bermúdez-Gallardo Marina M Serrano-Pérez-Higueras Óscar Ó Cavodeassi Florencia F Sotillos Sol S Martín-Bermudo María D MD Márquez Alberto A Buceta Javier J Escudero Luis M LM

Nature communications 20180727 1

As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term "scutoid". Th ...[more]

PMID: 30054479

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Dataset Information

Scutoids are a geometrical solution to three-dimensional packing of epithelia.

Publications

Scutoids are a geometrical solution to three-dimensional packing of epithelia.

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