Ontology highlight
ABSTRACT:
SUBMITTER: Muliaditan T
PROVIDER: S-EPMC6063977 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Muliaditan Tamara T Caron Jonathan J Okesola Mary M Opzoomer James W JW Kosti Paris P Georgouli Mirella M Gordon Peter P Lall Sharanpreet S Kuzeva Desislava M DM Pedro Luisa L Shields Jacqueline D JD Gillett Cheryl E CE Diebold Sandra S SS Sanz-Moreno Victoria V Ng Tony T Hoste Esther E Arnold James N JN
Nature communications 20180727 1
Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also found in human breast cancer, represent a macrophage phenotype similar to that observed during the wound healing response. Importantly, the expression of a wound-like cytokine response ...[more]