Ontology highlight
ABSTRACT:
SUBMITTER: Nosbaum A
PROVIDER: S-EPMC4761457 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20160129 5
Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control inflammation and mediate tissue-specific functions. The skin of mice and humans contain a large number of Tregs; however, the mechanisms of how these cells function in skin remain largely unknown. In this article, we show that Tregs facilitate cutaneous wound healing. Highly activated Tregs accumulated in skin early after wounding, and specific ablation of these cells resulted in delayed wound re-epithelialization a ...[more]