Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma.
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ABSTRACT:
SUBMITTER: Ott PA
PROVIDER: S-EPMC6064631 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma.
Ott Patrick A PA Hu Zhuting Z Keskin Derin B DB Shukla Sachet A SA Sun Jing J Bozym David J DJ Zhang Wandi W Luoma Adrienne A Giobbie-Hurder Anita A Peter Lauren L Chen Christina C Olive Oriol O Carter Todd A TA Li Shuqiang S Lieb David J DJ Eisenhaure Thomas T Gjini Evisa E Stevens Jonathan J Lane William J WJ Javeri Indu I Nellaiappan Kaliappanadar K Salazar Andres M AM Daley Heather H Seaman Michael M Buchbinder Elizabeth I EI Yoon Charles H CH Harden Maegan M Lennon Niall N Gabriel Stacey S Rodig Scott J SJ Barouch Dan H DH Aster Jon C JC Getz Gad G Wucherpfennig Kai K Neuberg Donna D Ritz Jerome J Lander Eric S ES Fritsch Edward F EF Hacohen Nir N Wu Catherine J CJ
Nature 20180301 7696
This corrects the article DOI: 10.1038/nature22991. ...[more]
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Project description:Personal neoantigen vaccines have been envisioned as an effective approach to induce, amplify and diversify antitumor T cell responses. To define the long-term effects of such a vaccine, we evaluated the clinical outcome and circulating immune responses of eight patients with surgically resected stage IIIB/C or IVM1a/b melanoma, at a median of almost 4 years after treatment with NeoVax, a long-peptide vaccine targeting up to 20 personal neoantigens per patient ( NCT01970358 ). All patients were alive and six were without evidence of active disease. We observed long-term persistence of neoantigen-specific T cell responses following vaccination, with ex vivo detection of neoantigen-specific T cells exhibiting a memory phenotype. We also found diversification of neoantigen-specific T cell clones over time, with emergence of multiple T cell receptor clonotypes exhibiting distinct functional avidities. Furthermore, we detected evidence of tumor infiltration by neoantigen-specific T cell clones after vaccination and epitope spreading, suggesting on-target vaccine-induced tumor cell killing. Personal neoantigen peptide vaccines thus induce T cell responses that persist over years and broaden the spectrum of tumor-specific cytotoxicity in patients with melanoma.
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