Ontology highlight
ABSTRACT:
SUBMITTER: Gualdoni GA
PROVIDER: S-EPMC6065033 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Gualdoni Guido A GA Mayer Katharina A KA Kapsch Anna-Maria AM Kreuzberg Katharina K Puck Alexander A Kienzl Philip P Oberndorfer Felicitas F Frühwirth Karin K Winkler Stefan S Blaas Dieter D Zlabinger Gerhard J GJ Stöckl Johannes J
Proceedings of the National Academy of Sciences of the United States of America 20180709 30
Rhinoviruses (RVs) are responsible for the majority of upper airway infections; despite their high prevalence and the resulting economic burden, effective treatment is lacking. We report here that RV induces metabolic alterations in host cells, which offer an efficient target for antiviral intervention. We show that RV-infected cells rapidly up-regulate glucose uptake in a PI3K-dependent manner. In parallel, infected cells enhance the expression of the PI3K-regulated glucose transporter GLUT1. I ...[more]