Unknown

Dataset Information

0

Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling.


ABSTRACT: Aberrant DNA methylation patterns in malignant cells allow insight into tumor evolution and development and can be used for disease classification. Here, we describe the genome-wide DNA methylation signatures of NPM-ALK-positive (ALK+) and NPM-ALK-negative (ALK-) anaplastic large-cell lymphoma (ALCL). We find that ALK+ and ALK- ALCL share common DNA methylation changes for genes involved in T cell differentiation and immune response, including TCR and CTLA-4, without an ALK-specific impact on tumor DNA methylation in gene promoters. Furthermore, we uncover a close relationship between global ALCL DNA methylation patterns and those in distinct thymic developmental stages and observe tumor-specific DNA hypomethylation in regulatory regions that are enriched for conserved transcription factor binding motifs such as AP1. Our results indicate similarity between ALCL tumor cells and thymic T cell subsets and a direct relationship between ALCL oncogenic signaling and DNA methylation through transcription factor induction and occupancy.

SUBMITTER: Hassler MR 

PROVIDER: S-EPMC6066089 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications


Aberrant DNA methylation patterns in malignant cells allow insight into tumor evolution and development and can be used for disease classification. Here, we describe the genome-wide DNA methylation signatures of NPM-ALK-positive (ALK+) and NPM-ALK-negative (ALK-) anaplastic large-cell lymphoma (ALCL). We find that ALK+ and ALK- ALCL share common DNA methylation changes for genes involved in T cell differentiation and immune response, including TCR and CTLA-4, without an ALK-specific impact on tu  ...[more]

Similar Datasets

2015-04-01 | GSE66881 | GEO
| S-EPMC6361572 | biostudies-literature
| S-EPMC4013413 | biostudies-literature
| S-EPMC2596920 | biostudies-literature
| S-EPMC5013897 | biostudies-literature
2013-09-20 | GSE50253 | GEO
| S-EPMC3778551 | biostudies-other
| S-EPMC4559938 | biostudies-literature
| S-EPMC2762475 | biostudies-literature
| S-EPMC6395348 | biostudies-literature