Ontology highlight
ABSTRACT:
SUBMITTER: Hassler MR
PROVIDER: S-EPMC6066089 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Hassler Melanie R MR Pulverer Walter W Lakshminarasimhan Ranjani R Redl Elisa E Hacker Julia J Garland Gavin D GD Merkel Olaf O Schiefer Ana-Iris AI Simonitsch-Klupp Ingrid I Kenner Lukas L Weisenberger Daniel J DJ Weinhaeusel Andreas A Turner Suzanne D SD Egger Gerda G
Cell reports 20161001 2
Aberrant DNA methylation patterns in malignant cells allow insight into tumor evolution and development and can be used for disease classification. Here, we describe the genome-wide DNA methylation signatures of NPM-ALK-positive (ALK+) and NPM-ALK-negative (ALK-) anaplastic large-cell lymphoma (ALCL). We find that ALK+ and ALK- ALCL share common DNA methylation changes for genes involved in T cell differentiation and immune response, including TCR and CTLA-4, without an ALK-specific impact on tu ...[more]