Dataset Information

PMEX01, a 70kb plasmid isolated from Escherichia coli that confers resistance to multiple ?-lactam antibiotics.

ABSTRACT: Multidrug-resistant microorganisms are of great concern to public health. Genetic mobile elements, such as plasmids, are among the most relevant mechanisms by which bacteria achieve this resistance. We obtained an Escherichia coli strain CM6, isolated from cattle presenting severe diarrheic symptoms in the State of Querétaro, Mexico. It was found to contain a 70kb plasmid (pMEX01) with a high similarity to the pHK01-like plasmids that were previously identified and described in Hong Kong. Analysis of the pMEX01 sequence revealed the presence of a blaCTX-M-14 gene, which is responsible for conferring resistance to multiple ?-lactam antibiotics. Several genes putatively involved in the conjugative transfer were also identified on the plasmid. The strain CM6 is of high epidemiological concern because it not only displays resistance to multiple ?-lactam antibiotics but also to other kinds of antibiotics.

SUBMITTER: Hernandez-Flores JL

PROVIDER: S-EPMC6066732 | biostudies-literature | 2018 Jul - Sep

REPOSITORIES: biostudies-literature

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pMEX01, a 70kb plasmid isolated from Escherichia coli that confers resistance to multiple β-lactam antibiotics.

Hernandez-Flores Jose Luis JL Pérez Juan Caballero JC Gutiérrez Carlos Saldaña CS Hernández Andrés Cruz AC Alonso Gerardo Soto GS Hernández Sergio Pacheco SP Gómez Sergio Romero SR Fernández Francisco F Loske Achim M AM Guillén Juan Campos JC

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 20180203 3

Multidrug-resistant microorganisms are of great concern to public health. Genetic mobile elements, such as plasmids, are among the most relevant mechanisms by which bacteria achieve this resistance. We obtained an Escherichia coli strain CM6, isolated from cattle presenting severe diarrheic symptoms in the State of Querétaro, Mexico. It was found to contain a 70kb plasmid (pMEX01) with a high similarity to the pHK01-like plasmids that were previously identified and described in Hong Kong. Analys ...[more]

PMID: 29449172

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Dataset Information

PMEX01, a 70kb plasmid isolated from Escherichia coli that confers resistance to multiple ?-lactam antibiotics.

Publications

pMEX01, a 70kb plasmid isolated from Escherichia coli that confers resistance to multiple β-lactam antibiotics.

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