Ontology highlight
ABSTRACT:
SUBMITTER: Caveney NA
PROVIDER: S-EPMC6478713 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Caveney Nathanael A NA Caballero Guillermo G Voedts Henri H Niciforovic Ana A Worrall Liam J LJ Vuckovic Marija M Fonvielle Matthieu M Hugonnet Jean-Emmanuel JE Arthur Michel M Strynadka Natalie C J NCJ
Nature communications 20190423 1
The bacterial cell wall plays a crucial role in viability and is an important drug target. In Escherichia coli, the peptidoglycan crosslinking reaction to form the cell wall is primarily carried out by penicillin-binding proteins that catalyse D,D-transpeptidase activity. However, an alternate crosslinking mechanism involving the L,D-transpeptidase YcbB can lead to bypass of D,D-transpeptidation and beta-lactam resistance. Here, we show that the crystallographic structure of YcbB consists of a c ...[more]