Ontology highlight
ABSTRACT:
SUBMITTER: Farfan N
PROVIDER: S-EPMC6068163 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Farfán Nancy N Ocarez Nallatt N Castellón Enrique A EA Mejía Nilo N de Herreros Antonio García AG Contreras Héctor R HR
Scientific reports 20180731 1
Syndecan 1 (SDC-1) is a cell surface proteoglycan with a significant role in cell adhesion, maintaining epithelial integrity. SDC1 expression is inversely related to aggressiveness in prostate cancer (PCa). During epithelial to mesenchymal transition (EMT), loss of epithelial markers is mediated by transcriptional repressors such as SNAIL, SLUG, or ZEB1/2 that bind to E-box promoter sequences of specific genes. The effect of these repressors on SDC-1 expression remains unknown. Here, we demonstr ...[more]