Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC6068179 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Zhang Huimin H Xue Rufeng R Zhu Shasha S Fu Sicheng S Chen Zuolong Z Zhou Rongbin R Tian Zhigang Z Bai Li L
Cellular & molecular immunology 20170410 5
Metaflammation is responsible for several metabolic syndromes, such as type 2 diabetes. However, the mechanisms by which metabolic disorders trigger metaflammation remain unclear. We identified a cell type-specific downregulation of CD1d expression in M2 macrophages during the progression of obesity prior to the onset of inflammation in visceral adipose tissues. A reduction in CD1d expression influenced the ability of M2 macrophages to present antigens and caused a change in antigen-presenting c ...[more]