Ontology highlight
ABSTRACT:
SUBMITTER: Bowyer G
PROVIDER: S-EPMC6068239 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bowyer Georgina G Grobbelaar Amy A Rampling Tommy T Venkatraman Navin N Morelle Danielle D Ballou Ripley W RW Hill Adrian V S AVS Ewer Katie J KJ
Frontiers in immunology 20180725
A malaria vaccine strategy targeting multiple lifecycle stages may be required to achieve a high level of efficacy. In two Phase IIa clinical trials, we tested immunogenicity and efficacy of RTS,S/AS01B administered alone, in a staggered regimen with viral-vectored vaccines or co-administered with viral-vectored vaccines. RTS,S/AS01B induces high titers of antibody against sporozoites and viral-vectored vaccines ChAd63 ME-TRAP and MVA ME-TRAP induce potent T cell responses against infected hepat ...[more]