Ontology highlight
ABSTRACT:
SUBMITTER: Moon JE
PROVIDER: S-EPMC7552430 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Moon James E JE Ockenhouse Christian C Regules Jason A JA Vekemans Johan J Lee Cynthia C Chuang Ilin I Traskine Magali M Jongert Erik E Ivinson Karen K Morelle Danielle D Komisar Jack L JL Lievens Marc M Sedegah Martha M Garver Lindsey S LS Sikaffy April K AK Waters Norman C NC Ballou William Ripley WR Ofori-Anyinam Opokua O
The Journal of infectious diseases 20201001 10
<h4>Background</h4>A previous RTS,S/AS01B vaccine challenge trial demonstrated that a 3-dose (0-1-7-month) regimen with a fractional third dose can produce high vaccine efficacy (VE) in adults challenged 3 weeks after vaccination. This study explored the VE of different delayed fractional dose regimens of adult and pediatric RTS,S/AS01 formulations.<h4>Methods</h4>A total of 130 participants were randomized into 5 groups. Four groups received 3 doses of RTS,S/AS01B or RTS,S/AS01E on a 0-1-7-mont ...[more]