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BioBits™ Bright: A fluorescent synthetic biology education kit.

ABSTRACT: Synthetic biology offers opportunities for experiential educational activities at the intersection of the life sciences, engineering, and design. However, implementation of hands-on biology activities in classrooms is challenging because of the need for specialized equipment and expertise to grow living cells. We present BioBits™ Bright, a shelf-stable, just-add-water synthetic biology education kit with easy visual outputs enabled by expression of fluorescent proteins in freeze-dried, cell-free reactions. We introduce activities and supporting curricula for teaching the central dogma, tunable protein expression, and design-build-test cycles and report data generated by K-12 teachers and students. We also develop inexpensive incubators and imagers, resulting in a comprehensive kit costing

SUBMITTER: Stark JC 

PROVIDER: S-EPMC6070313 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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BioBits™ Bright: A fluorescent synthetic biology education kit.

Stark Jessica C JC   Huang Ally A   Nguyen Peter Q PQ   Dubner Rachel S RS   Hsu Karen J KJ   Ferrante Thomas C TC   Anderson Mary M   Kanapskyte Ada A   Mucha Quinn Q   Packett Jessica S JS   Patel Palak P   Patel Richa R   Qaq Deema D   Zondor Tyler T   Burke Julie J   Martinez Thomas T   Miller-Berry Ashlee A   Puppala Aparna A   Reichert Kara K   Schmid Miriam M   Brand Lance L   Hill Lander R LR   Chellaswamy Jemima F JF   Faheem Nuhie N   Fetherling Suzanne S   Gong Elissa E   Gonzalzles Eddie Marie EM   Granito Teresa T   Koritsaris Jenna J   Nguyen Binh B   Ottman Sujud S   Palffy Christina C   Patel Angela A   Skweres Sheila S   Slaton Adriane A   Woods TaRhonda T   Donghia Nina N   Pardee Keith K   Collins James J JJ   Jewett Michael C MC  

Science advances 20180801 8

Synthetic biology offers opportunities for experiential educational activities at the intersection of the life sciences, engineering, and design. However, implementation of hands-on biology activities in classrooms is challenging because of the need for specialized equipment and expertise to grow living cells. We present BioBits™ Bright, a shelf-stable, just-add-water synthetic biology education kit with easy visual outputs enabled by expression of fluorescent proteins in freeze-dried, cell-free  ...[more]

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