Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC6070517 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Cell death & disease 20180801 8
Excessive cholesterol contributes to the development of cardiovascular diseases. Berberine (BBR) has been reported to regulate cholesterol homeostasis. Here, we found that BBR could ameliorate the hepatic autophagic flux blockade caused by cholesterol overloading. The underlying mechanism included lowering hepatic cholesterol level, modulating the cholesterol distribution targeting the plasma membrane by decreasing sterol carrier protein 2 expression and inhibiting cyclooxygenase 2-mediated prod ...[more]