Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC6533566 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chen Xiaoting X Chan Hung H Zhang Lin L Liu Xiaodong X Ho Idy H T IHT Zhang Xiang X Ho Jeffery J Hu Wei W Tian Yuanyuan Y Kou Shanglong S Chan Chee Sam CS Yu Jun J Wong Sunny H SH Gin Tony T Chan Matthew T V MTV Sun Xuegang X Wu William K K WKK
Journal of cellular and molecular medicine 20190411 6
Impaired autophagic degradation of intracellular lipids is causally linked to the development of non-alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic autophagic flux could therefore have therapeutic potentials for this increasingly prevalent disease. Herein, we investigated the effects of polydatin, a natural precursor of resveratrol, in a murine nutritional model of NASH and a cell line model of steatosis. Results showed that oral administration of polydatin pro ...[more]