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Applications of Yeast Synthetic Biology Geared towards the Production of Biopharmaceuticals.

ABSTRACT: Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minireview presents an overview of synthetic biology applications for the heterologous biosynthesis of biopharmaceuticals in yeast and demonstrates the power and potential of yeast cell factories by highlighting several recent examples. In addition, an outline of emerging trends in this rapidly-developing area is discussed, hinting upon the potential state-of-the-art in the years ahead.

SUBMITTER: Walker RSK

PROVIDER: S-EPMC6070867 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Applications of Yeast Synthetic Biology Geared towards the Production of Biopharmaceuticals.

Walker Roy S K RSK Pretorius Isak S IS

Genes 20180706 7

Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minireview presents an overview of synthetic biology applications for the heterologous biosynthesis of biopharmaceuticals in yeast and demonstrates the power and potential of yeast cell fac ...[more]

PMID: 29986380

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