Ontology highlight
ABSTRACT:
SUBMITTER: Shi M
PROVIDER: S-EPMC6071020 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Genes 20180627 7
Although a number of methods have been proposed for identifying differentially expressed pathways (DEPs), few efforts consider the dynamic components of pathway networks, i.e., gene links. We here propose a signaling dynamics detection method for identification of DEPs, DynSig, which detects the molecular signaling changes in cancerous cells along pathway topology. Specifically, DynSig relies on gene links, instead of gene nodes, in pathways, and models the dynamic behavior of pathways based on ...[more]