Ontology highlight
ABSTRACT:
SUBMITTER: Kossatz S
PROVIDER: S-EPMC6071506 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Kossatz Susanne S Carney Brandon B Farley Christopher C Weber Wolfgang A WA Drain Charles M CM Reiner Thomas T
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20180323 8
Poly(ADP-ribose)polymerase (PARP) inhibitors have emerged as potent antitumor drugs. Here, we describe the intrinsic fluorescence properties of the clinically approved PARP inhibitor rucaparib and its potential to directly measure drug distribution and target engagement-a critical factor for understanding drug action and improving efficacy. <b>Methods:</b> We characterized the photophysical properties of rucaparib and determined its quantum yield and lifetime. Using confocal microscopy and flow ...[more]