Ontology highlight
ABSTRACT:
SUBMITTER: Carney B
PROVIDER: S-EPMC5766608 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Carney Brandon B Kossatz Susanne S Lok Benjamin H BH Schneeberger Valentina V Gangangari Kishore K KK Pillarsetty Naga Vara Kishore NVK Weber Wolfgang A WA Rudin Charles M CM Poirier John T JT Reiner Thomas T
Nature communications 20180112 1
Insufficient chemotherapy response and rapid disease progression remain concerns for small-cell lung cancer (SCLC). Oncologists rely on serial CT scanning to guide treatment decisions, but this cannot assess in vivo target engagement of therapeutic agents. Biomarker assessments in biopsy material do not assess contemporaneous target expression, intratumoral drug exposure, or drug-target engagement. Here, we report the use of PARP1/2-targeted imaging to measure target engagement of PARP inhibitor ...[more]